This volume presents a proven psychoeducational therapy approach for persons with severe mental illness and their families. Pioneering schizophrenia treatment developer William R. McFarlane first lays out the theoretical and empirical foundations of the multifamily model. Chapters coauthored with other leading clinician-researchers then provide detailed “how-to” instructions for forming groups; implementing educational and problem-solving interventions; managing clinical, relationship, and functional issues that may arise; and integrating psychoeducation with other forms of treatment. Also addressed are applications of the model—some described here for the first time—to a variety of disorders other than schizophrenia, including bipolar disorder, depression, obsessive-compulsive disorder, borderline personality disorder, and medical illness.