From pioneering clinician-researchers, this book provides crucial guidance for treating co-occurring concerns that virtually all therapists are likely to encounter—and many feel ill equipped to handle. Denise Hien and Lisa Caren Litt review the landscape of evidence-based treatments for posttraumatic stress disorder (PTSD), other trauma-related problems, and substance misuse, and present an integrative, culturally responsive framework for assessment and treatment planning. The book shows the clinician how to navigate the complexities of the treatment process while tailoring interventions flexibly and collaboratively to each client's needs. Rich clinical examples include two extended cases that run throughout the chapters. The companion website features several reproducible clinical tools and a comprehensive resource list.